Posted in Antibodies, Assay Kits, Biology Cells, cDNA, Clia Kits, Culture Cells, Devices, DNA, DNA Templates, DNA Testing, Elisa Kits, Enzymes, Equipments, Exosomes, Gels, Isotypes, Medium & Serums, NATtrol, Panel, Particles, PCR, Pcr Kits, Peptides, Reagents, Recombinant Proteins, Ria Kits, RNA, Vector & Virus
Best Okadaic acid and Ammonium Salt
The construction and regulation of protein phosphatases.
- 4 main serine/threonine-specific protein phosphatase catalytic subunits are current within the cytoplasm of animal cells. Three of those enzymes, PP-1, PP-2A, and PP-2B, are members of the identical gene household, whereas PP-2C seems to be distinct. PP-1, PP-2A, and PP-2B are complexed to different subunits in vivo, whereas PP-2C has solely been remoted as a monomeric protein. PP-1, PP-2A, and PP-2C have broad and overlapping specificities in vitro, and account for just about all measurable exercise in tissue extracts towards a wide range of phosphoproteins that regulate metabolism, muscle contractility, and different processes.
- Their exact capabilities in vivo are unknown, though necessary clues to the physiological roles of PP-1 and PP-2A are supplied by the results of okadaic acid and by the subcellular localization of PP-1. The energetic types of PP-1 are largely particulate, and their affiliation with subcellular buildings is mediated by “targetting subunits” that direct PP-1 to specific areas, improve its exercise towards sure substrates, and confer necessary regulatory properties upon it.
Fosamprenavir Calcium Salt | MLN4924 HCl salt
- This idea is finest established for the glycogen-bound enzymes in skeletal muscle and liver (PP-1G) and the myofibrillar type (PP-1M) in skeletal muscle. The actions of PP-1 and PP-2B are managed by the second messengers cyclic AMP and calcium. The exercise of PP-2B depends on calcium and calmodulin, whereas PP-1 is managed in a wide range of ways in which rely upon the type of the enzyme and the tissue. PP-1 may be inhibited by cyclic AMP in a wide range of cells by means of the A-kinase-catalyzed phosphorylation of inhibitor-1 and its isofobrms.
- Phosphorylation of the glycogen-binding subunit of PP-1G by A-kinase promotes translocation of the catalytic subunit from glycogen particles to cytosol in skeletal muscle, inhibiting the dephosphorylation of glycogen-metabolizing enzymes.
Tariquidar methanesulfonate, hydrate
- Allosteric inhibition of hepatic PP-1G by phosphorylase a happens in response to alerts that elevate cyclic AMP or calcium, and prevents the activation of glycogen synthase in liver. PP-1 can be activated not directly by calcium by means of the power of PP-2B to dephosphorylate inhibitor-1.
- This management mechanism might function in dopaminoceptive neurones of the mind and different cells. The inactive cytosolic type of PP-1 (PP-1I) may be activated in vitro by means of the glycogen synthase kinase-3-catalyzed phosphorylation of its inhibitory subunit (inhibitor-2), however the physiological significance is unclear.(ABSTRACT TRUNCATED AT 400 WORDS)

17-DMAG, Hydrochloride Salt, >98% |
BC024-001 |
GenDepot |
1mg |
EUR 178 |
17-DMAG, Hydrochloride Salt, >98% |
BC024-005 |
GenDepot |
5mg |
EUR 286 |
17-DMAG, Hydrochloride Salt, >98% |
BC024-010 |
GenDepot |
10mg |
EUR 408 |
17-DMAG, Hydrochloride Salt, >98% |
BC024-025 |
GenDepot |
25mg |
Ask for price |
17-DMAG, Hydrochloride Salt, >99% |
BC024-100 |
GenDepot |
100mg |
Ask for price |
17-DMAG, Hydrochloride Salt, >99% |
BC024-101 |
GenDepot |
1g |
Ask for price |
17-DMAG, Hydrochloride Salt, >99% |
BC024-250 |
GenDepot |
250mg |
Ask for price |
OSU-03012, Hydrochloride Salt, >98% |
BC061-005 |
GenDepot |
5mg |
EUR 313 |
OSU-03012, Hydrochloride Salt, >98% |
BC061-025 |
GenDepot |
25mg |
EUR 529 |
Bile salt |
BB0225 |
BBI Biotech |
25g |
EUR 79.58 |
- Product category: Biochemicals/Detergents/Surfactants
|
Stachydrine (hydrochloride) |
C3648-100 |
ApexBio |
100 mg |
EUR 119 |
Description: Stachydrine is an anti-metastatic agent.Stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits. |
Stachydrine (hydrochloride) |
C3648-1000 |
ApexBio |
1 g |
EUR 467 |
Description: Stachydrine is an anti-metastatic agent.Stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits. |
Stachydrine (hydrochloride) |
C3648-250 |
ApexBio |
250 mg |
EUR 206 |
Description: Stachydrine is an anti-metastatic agent.Stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits. |
Stachydrine (hydrochloride) |
C3648-500 |
ApexBio |
500 mg |
EUR 328 |
Description: Stachydrine is an anti-metastatic agent.Stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits. |
Barnidipine (hydrochloride) |
C3727-100 |
ApexBio |
100 mg |
EUR 203 |
Description: Barnidipine is a calcium-channel blocker.A calcium channel, an ion channel which displays selective permeability to calcium ions, is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. |
Barnidipine (hydrochloride) |
C3727-50 |
ApexBio |
50 mg |
EUR 155 |
Description: Barnidipine is a calcium-channel blocker.A calcium channel, an ion channel which displays selective permeability to calcium ions, is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. |
MS049 (hydrochloride) |
C3776-10 |
ApexBio |
10 mg |
EUR 200 |
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor. |
MS049 (hydrochloride) |
C3776-100 |
ApexBio |
100 mg |
EUR 1181 |
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor. |
MS049 (hydrochloride) |
C3776-25 |
ApexBio |
25 mg |
EUR 382 |
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor. |
MS049 (hydrochloride) |
C3776-5 |
ApexBio |
5 mg |
EUR 139 |
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor. |
MS049 (hydrochloride) |
C3776-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 150 |
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor. |
MS049 (hydrochloride) |
C3776-50 |
ApexBio |
50 mg |
EUR 653 |
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor. |
Guanabenz (hydrochloride) |
C3786-100 |
ApexBio |
100 mg |
EUR 231 |
Description: Guanabenz is an orally active ?2-adrenoceptor agonist with hypotensive effects [1]. The ?2 adrenergic receptors belong to a family of G protein-coupled receptor (GPCR), mediate many physiological actions of the endogenous catecholamines adrenaline and noradrenaline. |
Guanabenz (hydrochloride) |
C3786-50 |
ApexBio |
50 mg |
EUR 144 |
Description: Guanabenz is an orally active ?2-adrenoceptor agonist with hypotensive effects [1]. The ?2 adrenergic receptors belong to a family of G protein-coupled receptor (GPCR), mediate many physiological actions of the endogenous catecholamines adrenaline and noradrenaline. |
Ulixertinib (hydrochloride) |
C3921-10 |
ApexBio |
10 mg |
EUR 406 |
Description: Ulixertinib, also named as BVD-523, is a novel and reversible inhibitor of ERK1/2. Ulixertinib potently and selectively inhibits the activity of ERK1 and ERK2 kinases in a reversible, ATP-competitive fashion [1]. |
Ulixertinib (hydrochloride) |
C3921-25 |
ApexBio |
25 mg |
EUR 661 |
Description: Ulixertinib, also named as BVD-523, is a novel and reversible inhibitor of ERK1/2. Ulixertinib potently and selectively inhibits the activity of ERK1 and ERK2 kinases in a reversible, ATP-competitive fashion [1]. |
Ulixertinib (hydrochloride) |
C3921-5 |
ApexBio |
5 mg |
EUR 250 |
Description: Ulixertinib, also named as BVD-523, is a novel and reversible inhibitor of ERK1/2. Ulixertinib potently and selectively inhibits the activity of ERK1 and ERK2 kinases in a reversible, ATP-competitive fashion [1]. |
Chlorcyclizine (hydrochloride) |
C3989-100 |
ApexBio |
100 mg |
EUR 118 |
Description: Chlorcyclizine is a phenylpiperazine antagonist for histamine H1 receptor [1]. The histamine has been involved in modulating many physiological functions of the hypothalamus, such as arousal state, feeding, locomotor activity, and drinking. |
Chlorcyclizine (hydrochloride) |
C3989-1000 |
ApexBio |
1 g |
EUR 595 |
Description: Chlorcyclizine is a phenylpiperazine antagonist for histamine H1 receptor [1]. The histamine has been involved in modulating many physiological functions of the hypothalamus, such as arousal state, feeding, locomotor activity, and drinking. |
Chlorcyclizine (hydrochloride) |
C3989-250 |
ApexBio |
250 mg |
EUR 210 |
Description: Chlorcyclizine is a phenylpiperazine antagonist for histamine H1 receptor [1]. The histamine has been involved in modulating many physiological functions of the hypothalamus, such as arousal state, feeding, locomotor activity, and drinking. |
Chlorcyclizine (hydrochloride) |
C3989-500 |
ApexBio |
500 mg |
EUR 357 |
Description: Chlorcyclizine is a phenylpiperazine antagonist for histamine H1 receptor [1]. The histamine has been involved in modulating many physiological functions of the hypothalamus, such as arousal state, feeding, locomotor activity, and drinking. |
Lofexidine (hydrochloride) |
C3990-1000 |
ApexBio |
1 g |
EUR 126 |
Description: Lofexidine is a ?2-Receptor agonist for opioid detoxification. Lofexidine shows a strong affinity for the ?2A-receptor subtype [1]. |
Lofexidine (hydrochloride) |
C3990-5.1 |
ApexBio |
10 mM (in 1mL H2O) |
EUR 113 |
Description: Lofexidine is a ?2-Receptor agonist for opioid detoxification. Lofexidine shows a strong affinity for the ?2A-receptor subtype [1]. |
Lofexidine (hydrochloride) |
C3990-500 |
ApexBio |
500 mg |
EUR 100 |
Description: Lofexidine is a ?2-Receptor agonist for opioid detoxification. Lofexidine shows a strong affinity for the ?2A-receptor subtype [1]. |
Nortriptyline (hydrochloride) |
C4077-100 |
ApexBio |
100 mg |
EUR 163 |
Description: Ki: 3.4 nM: blocks the norepinephrine transporter.Ki: 161 nM: inhibits the serotonin transporter. |
Nortriptyline (hydrochloride) |
C4077-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 113 |
Description: Ki: 3.4 nM: blocks the norepinephrine transporter.Ki: 161 nM: inhibits the serotonin transporter. |
Nortriptyline (hydrochloride) |
C4077-50 |
ApexBio |
50 mg |
EUR 116 |
Description: Ki: 3.4 nM: blocks the norepinephrine transporter.Ki: 161 nM: inhibits the serotonin transporter. |
Imipramine (hydrochloride) |
C4117-5.1 |
ApexBio |
10 mM (in 1mL H2O) |
EUR 113 |
Description: Imipramine (hydrochloride) is a tricyclic antidepressant and is mainly used in the treatment of major depression and enuresis [1]. Antidepressants are antagonists of many neurotransmitter receptors in human brain [3]. |
Imipramine (hydrochloride) |
C4117-5000 |
ApexBio |
5 g |
EUR 108 |
Description: Imipramine (hydrochloride) is a tricyclic antidepressant and is mainly used in the treatment of major depression and enuresis [1]. Antidepressants are antagonists of many neurotransmitter receptors in human brain [3]. |
Clorgyline (hydrochloride) |
C4137-100 |
ApexBio |
100 mg |
EUR 224 |
Description: Clorgyline (hydrochloride) is an irreversible, potent and selective monoamine oxidase (MAO) A inhibitor with Ki values of 0.054 and 58 ?M and IC50 values of 0.0012 and 1.9 ?M for MAO-A and MAO-B, respectively [1][2]. |
Clorgyline (hydrochloride) |
C4137-25 |
ApexBio |
25 mg |
EUR 110 |
Description: Clorgyline (hydrochloride) is an irreversible, potent and selective monoamine oxidase (MAO) A inhibitor with Ki values of 0.054 and 58 ?M and IC50 values of 0.0012 and 1.9 ?M for MAO-A and MAO-B, respectively [1][2]. |
Clorgyline (hydrochloride) |
C4137-50 |
ApexBio |
50 mg |
EUR 154 |
Description: Clorgyline (hydrochloride) is an irreversible, potent and selective monoamine oxidase (MAO) A inhibitor with Ki values of 0.054 and 58 ?M and IC50 values of 0.0012 and 1.9 ?M for MAO-A and MAO-B, respectively [1][2]. |
Doxepin (hydrochloride) |
C4153-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 113 |
Description: Doxepin, a tricyclic antidepressant, is a potent histamine H1 antagonist [1]. The histamine receptors belong to a family of G protein?coupled receptors activated by their primary endogenous ligand histamine. |
Doxepin (hydrochloride) |
C4153-5000 |
ApexBio |
5 g |
EUR 168 |
Description: Doxepin, a tricyclic antidepressant, is a potent histamine H1 antagonist [1]. The histamine receptors belong to a family of G protein?coupled receptors activated by their primary endogenous ligand histamine. |
Anhydrochlortetracycline (hydrochloride) |
C4218-1 |
ApexBio |
1 mg |
EUR 132 |
Description: Anhydrochlortetracycline was produced by the acid degradation of chlortetracycline. Anhydrochlortetracycline only have a fraction of the antibacterial activity of chlortetracycline. Anhydrochlortetracycline strongly inhibited the growth of Streptomyces aureofaciem. |
Anhydrochlortetracycline (hydrochloride) |
C4218-5 |
ApexBio |
5 mg |
EUR 255 |
Description: Anhydrochlortetracycline was produced by the acid degradation of chlortetracycline. Anhydrochlortetracycline only have a fraction of the antibacterial activity of chlortetracycline. Anhydrochlortetracycline strongly inhibited the growth of Streptomyces aureofaciem. |
Anhydrotetracycline (hydrochloride) |
C4291-100 |
ApexBio |
100 mg |
EUR 241 |
Description: Anhydrotetracycline (hydrochloride) (ATC) is a powerful effector for the tetracycline repressor (TetR) and reverse tetracycline repressor (revTetR) systems [1]. |
Anhydrotetracycline (hydrochloride) |
C4291-25 |
ApexBio |
25 mg |
EUR 123 |
Description: Anhydrotetracycline (hydrochloride) (ATC) is a powerful effector for the tetracycline repressor (TetR) and reverse tetracycline repressor (revTetR) systems [1]. |
Anhydrotetracycline (hydrochloride) |
C4291-50 |
ApexBio |
50 mg |
EUR 171 |
Description: Anhydrotetracycline (hydrochloride) (ATC) is a powerful effector for the tetracycline repressor (TetR) and reverse tetracycline repressor (revTetR) systems [1]. |
(±)-Salsolinol (hydrochloride) |
C4364-500 |
ApexBio |
500 mg |
EUR 308 |
Description: (±)-Salsolinol targets depolarize dopamineric neurons. Dopaminergic neurons produce dopamine, a neurotransmitter with various roles in neurological functions. |
Midodrine (hydrochloride) |
C4493-100 |
ApexBio |
100 mg |
EUR 113 |
Description: Ki: 2, 6.9, and 1.7 ?M for ?1A, ?1B, ?1D, respectivelyMidodrine is the prodrug of the ?1-adrenergic receptor agonist, 1-(2?,5?-dimethoxyphenyl)-2-aminoethanol. |
Midodrine (hydrochloride) |
C4493-250 |
ApexBio |
250 mg |
EUR 200 |
Description: Ki: 2, 6.9, and 1.7 ?M for ?1A, ?1B, ?1D, respectivelyMidodrine is the prodrug of the ?1-adrenergic receptor agonist, 1-(2?,5?-dimethoxyphenyl)-2-aminoethanol. |
Celiprolol (hydrochloride) |
C4521-10 |
ApexBio |
10 mg |
EUR 254 |
Description: Celiprolol is a ?1 adrenergic receptor antagonist and ?2 adrenergic receptor partial agonist.?2 adrenergic receptor agonists, also known as adrenergic ?2 receptor agonists, are a class of drugs acting on the ?2 adrenergic receptor. |
Celiprolol (hydrochloride) |
C4521-25 |
ApexBio |
25 mg |
EUR 500 |
Description: Celiprolol is a ?1 adrenergic receptor antagonist and ?2 adrenergic receptor partial agonist.?2 adrenergic receptor agonists, also known as adrenergic ?2 receptor agonists, are a class of drugs acting on the ?2 adrenergic receptor. |
Celiprolol (hydrochloride) |
C4521-5 |
ApexBio |
5 mg |
EUR 183 |
Description: Celiprolol is a ?1 adrenergic receptor antagonist and ?2 adrenergic receptor partial agonist.?2 adrenergic receptor agonists, also known as adrenergic ?2 receptor agonists, are a class of drugs acting on the ?2 adrenergic receptor. |
Aceclidine (hydrochloride) |
C4635-1000 |
ApexBio |
1 g |
EUR 328 |
Aceclidine (hydrochloride) |
C4635-500 |
ApexBio |
500 mg |
EUR 206 |
Trimidox (hydrochloride) |
C4714-10 |
ApexBio |
10 mg |
EUR 184 |
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis. |
Trimidox (hydrochloride) |
C4714-25 |
ApexBio |
25 mg |
EUR 370 |
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis. |
Trimidox (hydrochloride) |
C4714-5 |
ApexBio |
5 mg |
EUR 121 |
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis. |
Trimidox (hydrochloride) |
C4714-50 |
ApexBio |
50 mg |
EUR 618 |
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis. |
Cycloguanil (hydrochloride) |
C5763-10 |
ApexBio |
10 mg |
EUR 109 |
Description: Cycloguanil is an inhibitor of dihydrofolate reductase (DHFR)[1].Dihydrofolate reductase (DHFR) is an enzyme that involved in reducing dihydrofolic acid to tetrahydrofolic acid. |
Cycloguanil (hydrochloride) |
C5763-25 |
ApexBio |
25 mg |
EUR 163 |
Description: Cycloguanil is an inhibitor of dihydrofolate reductase (DHFR)[1].Dihydrofolate reductase (DHFR) is an enzyme that involved in reducing dihydrofolic acid to tetrahydrofolic acid. |
Cycloguanil (hydrochloride) |
C5763-50 |
ApexBio |
50 mg |
EUR 206 |
Description: Cycloguanil is an inhibitor of dihydrofolate reductase (DHFR)[1].Dihydrofolate reductase (DHFR) is an enzyme that involved in reducing dihydrofolic acid to tetrahydrofolic acid. |
VU590 (hydrochloride) |
C4778-10 |
ApexBio |
10 mg |
EUR 195 |
VU590 (hydrochloride) |
C4778-25 |
ApexBio |
25 mg |
EUR 389 |
VU590 (hydrochloride) |
C4778-5 |
ApexBio |
5 mg |
EUR 139 |
Bufuralol (hydrochloride) |
C5043-1 |
ApexBio |
1 mg |
EUR 139 |
Description: Bufuralol is a non-specific ?-adrenergic blocker. Beta adrenergic agonists are medications relaxing muscles of the airways, which widens the airways and leads to easier breathing. |
Bufuralol (hydrochloride) |
C5043-10 |
ApexBio |
10 mg |
EUR 628 |
Description: Bufuralol is a non-specific ?-adrenergic blocker. Beta adrenergic agonists are medications relaxing muscles of the airways, which widens the airways and leads to easier breathing. |
Bufuralol (hydrochloride) |
C5043-5 |
ApexBio |
5 mg |
EUR 457 |
Description: Bufuralol is a non-specific ?-adrenergic blocker. Beta adrenergic agonists are medications relaxing muscles of the airways, which widens the airways and leads to easier breathing. |
AN3365 (hydrochloride) |
C5068-10 |
ApexBio |
10 mg |
EUR 328 |
Description: AN3365 is a potent and selective leucyl-tRNA synthetase inhibitor [1].The leucyl-tRNA synthetase belongs to a member of the class I aminoacyl-tRNA synthetase family. |
AN3365 (hydrochloride) |
C5068-25 |
ApexBio |
25 mg |
EUR 659 |
Description: AN3365 is a potent and selective leucyl-tRNA synthetase inhibitor [1].The leucyl-tRNA synthetase belongs to a member of the class I aminoacyl-tRNA synthetase family. |
AN3365 (hydrochloride) |
C5068-5 |
ApexBio |
5 mg |
EUR 206 |
Description: AN3365 is a potent and selective leucyl-tRNA synthetase inhibitor [1].The leucyl-tRNA synthetase belongs to a member of the class I aminoacyl-tRNA synthetase family. |
Calindol (hydrochloride) |
C5329-10 |
ApexBio |
10 mg |
EUR 440 |
Description: Calindol is an activator of the calcium-sensing receptor (CaSR).The extracellular calciumsensing receptor (CaSR), a G protein-coupled receptor (GPCR), senses extracellular calcium[Ca2+]e and regulates calciumion homeostasis. |
Calindol (hydrochloride) |
C5329-25 |
ApexBio |
25 mg |
EUR 902 |
Description: Calindol is an activator of the calcium-sensing receptor (CaSR).The extracellular calciumsensing receptor (CaSR), a G protein-coupled receptor (GPCR), senses extracellular calcium[Ca2+]e and regulates calciumion homeostasis. |
Calindol (hydrochloride) |
C5329-5 |
ApexBio |
5 mg |
EUR 270 |
Description: Calindol is an activator of the calcium-sensing receptor (CaSR).The extracellular calciumsensing receptor (CaSR), a G protein-coupled receptor (GPCR), senses extracellular calcium[Ca2+]e and regulates calciumion homeostasis. |
Kasugamycin (hydrochloride) |
C5503-10000 |
ApexBio |
10 g |
EUR 350 |
Description: Kasugamycin is an aminoglycosidic antibiotic. Aminoglycoside, a medicinal and bacteriologic category of traditional Gram-negative antibacterial therapeutic agent, inhibits protein synthesis and contains as a portion of the molecule an amino-modified glycoside. |
Kasugamycin (hydrochloride) |
C5503-5000 |
ApexBio |
5 g |
EUR 251 |
Description: Kasugamycin is an aminoglycosidic antibiotic. Aminoglycoside, a medicinal and bacteriologic category of traditional Gram-negative antibacterial therapeutic agent, inhibits protein synthesis and contains as a portion of the molecule an amino-modified glycoside. |
Ciprofloxacin (hydrochloride) |
C5539-10000 |
ApexBio |
10 g |
EUR 116 |
Description: Ciprofloxacin (hydrochloride) is a fluoroquinolone antibiotic that has antimicrobial and immunomodulatory activities [1]. |
Ciprofloxacin (hydrochloride) |
C5539-25000 |
ApexBio |
25 g |
EUR 154 |
Description: Ciprofloxacin (hydrochloride) is a fluoroquinolone antibiotic that has antimicrobial and immunomodulatory activities [1]. |
CTLA-Four and PD-1 receptors inhibit T-cell activation by distinct mechanisms.
- CTLA-Four and PD-1 are receptors that negatively regulate T-cell activation. Ligation of each CTLA-Four and PD-1 blocked CD3/CD28-mediated upregulation of glucose metabolism and Akt exercise, however every achieved this regulation utilizing separate mechanisms.
- CTLA-4-mediated inhibition of Akt phosphorylation is delicate to okadaic acid, offering direct proof that PP2A performs a distinguished function in mediating CTLA-Four suppression of T-cell activation. In distinction, PD-1 signaling inhibits Akt phosphorylation by stopping CD28-mediated activation of phosphatidylinositol 3-kinase (PI3K).
Palbociclib (PD0332991) Isethionate
- The power of PD-1 to suppress PI3K/AKT activation was dependent upon the immunoreceptor tyrosine-based change motif positioned in its cytoplasmic tail, including additional significance to this area in mediating PD-1 sign transduction.
- Lastly, PD-1 ligation is more practical in suppressing CD3/CD28-induced adjustments within the T-cell transcriptional profile, suggesting that differential regulation of PI3K activation by PD-1 and CTLA-Four ligation ends in distinct mobile phenotypes. Collectively, these knowledge counsel that CTLA-Four and PD-1 inhibit T-cell activation by means of distinct and doubtlessly synergistic mechanisms.
- The inhibitory impact of a marine-sponge toxin, okadaic acid, was examined on kind 1, kind 2A, kind 2B and kind 2C protein phosphatases in addition to on a polycation-modulated (PCM) phosphatase. Of the protein phosphatases examined, the catalytic subunit of kind 2A phosphatase from rabbit skeletal muscle was most potently inhibited. For the phosphorylated myosin light-chain
Colistin Methanesulfonate (sodium salt) |
C3046-1000 |
ApexBio |
1 g |
EUR 174 |
Description: Colistin methanesulfonate is an inactive prodrug of colistin (also known as polymyxin E), which is an antibiotic with effect against most Gram-negative bacteria, but also causes nephro- and neurotoxicity [1]. |
Colistin Methanesulfonate (sodium salt) |
C3046-5000 |
ApexBio |
5 g |
EUR 612 |
Description: Colistin methanesulfonate is an inactive prodrug of colistin (also known as polymyxin E), which is an antibiotic with effect against most Gram-negative bacteria, but also causes nephro- and neurotoxicity [1]. |
Ethyl methanesulfonate |
20-abx186442 |
Abbexa |
-
EUR 565.00
-
EUR 300.00
-
EUR 217.00
|
|
- Shipped within 1-2 weeks.
|
Pridinol Methanesulfonate |
A8507-1000 |
ApexBio |
1 g |
EUR 431 |
Description: Pridinol Methanesulfonate Salt is used as an anticholinergic and as an antiparkinsonian agent. |
Pridinol Methanesulfonate |
A8507-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 108 |
Description: Pridinol Methanesulfonate Salt is used as an anticholinergic and as an antiparkinsonian agent. |
Pridinol Methanesulfonate |
A8507-50 |
ApexBio |
50 mg |
EUR 128 |
Description: Pridinol Methanesulfonate Salt is used as an anticholinergic and as an antiparkinsonian agent. |
Pridinol Methanesulfonate |
A8507-5000 |
ApexBio |
5 g |
EUR 999 |
Description: Pridinol Methanesulfonate Salt is used as an anticholinergic and as an antiparkinsonian agent. |
Colistin Sodium Methanesulfonate |
C073-10G |
TOKU-E |
10 g |
EUR 820 |
Colistin Sodium Methanesulfonate |
C073-1G |
TOKU-E |
1 g |
EUR 135 |
Colistin Sodium Methanesulfonate |
C073-5G |
TOKU-E |
5 g |
EUR 440 |
Tariquidar (methanesulfonate, hydrate) |
HY-10550A |
MedChemExpress |
100mg |
EUR 612 |
Hydroxystilbamidine bis(methanesulfonate) |
HY-108166A |
MedChemExpress |
5mg |
EUR 533 |
PF-06424439 (methanesulfonate) |
HY-108341A |
MedChemExpress |
10mM/1mL |
EUR 146 |
PF-04217903 (methanesulfonate) |
HY-12017A |
MedChemExpress |
10mM/1mL |
EUR 156 |
2-Chloroethyl methanesulfonate |
20-abx183170 |
Abbexa |
|
|
- Shipped within 1-2 weeks.
|
PF-04217903 methanesulfonate |
A3712-100 |
ApexBio |
100 mg |
EUR 595 |
Description: PF-04217903 is an ATP-competitive small-molecule inhibitor of c-Met kinase with Ki value of 4.8 nM [1].The c-Met kinase is a kind of receptor tyrosine kinases (RTK) and plays critical roles in embryonic development and wound healing. |
PF-04217903 methanesulfonate |
A3712-25 |
ApexBio |
25 mg |
EUR 293 |
Description: PF-04217903 is an ATP-competitive small-molecule inhibitor of c-Met kinase with Ki value of 4.8 nM [1].The c-Met kinase is a kind of receptor tyrosine kinases (RTK) and plays critical roles in embryonic development and wound healing. |
PF-04217903 methanesulfonate |
A3712-5 |
ApexBio |
5 mg |
EUR 131 |
Description: PF-04217903 is an ATP-competitive small-molecule inhibitor of c-Met kinase with Ki value of 4.8 nM [1].The c-Met kinase is a kind of receptor tyrosine kinases (RTK) and plays critical roles in embryonic development and wound healing. |
Tariquidar methanesulfonate, hydrate |
A3859-10 |
ApexBio |
10 mg |
EUR 189 |
Description: Tariquidar methanesulfonate, hydrate is a potent inhibitor of P-glycoprotein (Pgp), a 170-kDa transmembrane protein acting as a drug efflux pump to actively transport structurally unrelated compounds out of cell, which noncompetitively inhibits the basal the activity of ATPase associated with Pgp. |
Tariquidar methanesulfonate, hydrate |
A3859-50 |
ApexBio |
50 mg |
EUR 444 |
Description: Tariquidar methanesulfonate, hydrate is a potent inhibitor of P-glycoprotein (Pgp), a 170-kDa transmembrane protein acting as a drug efflux pump to actively transport structurally unrelated compounds out of cell, which noncompetitively inhibits the basal the activity of ATPase associated with Pgp. |
Ethyl 3-Aminobenzoate (methanesulfonate) |
C3619-100000 |
ApexBio |
100 g |
EUR 318 |
Description: Ethyl 3-Aminobenzoate can block the generation of action potentials via voltage-dependent Na+-channels.Sodium channels play a critical role in physiology: they can rapidly transmit depolarizing impulses throughout cells and cell networks, therefore enabling co-ordination of higher processes. |
Ethyl 3-Aminobenzoate (methanesulfonate) |
C3619-25000 |
ApexBio |
25 g |
EUR 128 |
Description: Ethyl 3-Aminobenzoate can block the generation of action potentials via voltage-dependent Na+-channels.Sodium channels play a critical role in physiology: they can rapidly transmit depolarizing impulses throughout cells and cell networks, therefore enabling co-ordination of higher processes. |
Ethyl 3-Aminobenzoate (methanesulfonate) |
C3619-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 113 |
Description: Ethyl 3-Aminobenzoate can block the generation of action potentials via voltage-dependent Na+-channels.Sodium channels play a critical role in physiology: they can rapidly transmit depolarizing impulses throughout cells and cell networks, therefore enabling co-ordination of higher processes. |
Ethyl 3-Aminobenzoate (methanesulfonate) |
C3619-50000 |
ApexBio |
50 g |
EUR 195 |
Description: Ethyl 3-Aminobenzoate can block the generation of action potentials via voltage-dependent Na+-channels.Sodium channels play a critical role in physiology: they can rapidly transmit depolarizing impulses throughout cells and cell networks, therefore enabling co-ordination of higher processes. |
Ro 31-8220 methanesulfonate |
1946-1 |
Biovision |
|
EUR 137 |
Ro 31-8220 methanesulfonate |
1946-5 |
Biovision |
|
EUR 381 |
Bile salt |
BB0225 |
BBI Biotech |
25g |
EUR 79.58 |
- Product category: Biochemicals/Detergents/Surfactants
|
Ampicillin Sodium Salt |
AK0839-0010 |
Akron Biotech |
10g |
Ask for price |
Ampicillin Sodium Salt |
AK0839-0025 |
Akron Biotech |
25g |
Ask for price |
Ampicillin Sodium Salt |
AK0839-0100 |
Akron Biotech |
100g |
Ask for price |
NADPH Tetrasodium Salt |
AK1395-0100 |
Akron Biotech |
100mg |
Ask for price |
NADPH Tetrasodium Salt |
AK1395-0500 |
Akron Biotech |
500mg |
Ask for price |
NADPH Tetrasodium Salt |
AK1395-1000 |
Akron Biotech |
1g |
Ask for price |
CAPS, sodium salt |
CB0097 |
BBI Biotech |
50g |
EUR 71.75 |
- Product category: Biochemicals/Biological Buffers/Common Buffers
|
CAPSO, sodium salt |
CD0041 |
BBI Biotech |
50g |
EUR 76.1 |
- Product category: Biochemicals/Biological Buffers/Common Buffers
|
Cefonicid (sodium salt) |
C3812-1000 |
ApexBio |
1 g |
EUR 406 |
Description: Cefonicid is a second-generation cephalosporin antibiotic.Cephalosporins, the largest and most diverse family of antibiotics of the beta-lactam group, are structurally and pharmacologically related to the penicillins. |
Cefonicid (sodium salt) |
C3812-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 113 |
Description: Cefonicid is a second-generation cephalosporin antibiotic.Cephalosporins, the largest and most diverse family of antibiotics of the beta-lactam group, are structurally and pharmacologically related to the penicillins. |
Cefonicid (sodium salt) |
C3812-500 |
ApexBio |
500 mg |
EUR 251 |
Description: Cefonicid is a second-generation cephalosporin antibiotic.Cephalosporins, the largest and most diverse family of antibiotics of the beta-lactam group, are structurally and pharmacologically related to the penicillins. |
Cefoperazone (sodium salt) |
C3913-10000 |
ApexBio |
10 g |
EUR 403 |
Description: Cefoperazone is a new semisynthetic cephalosporin with a broad spectrum of antibacterial activity. Cefoperazone shows high activity against gram-positive bacteria and gram-negative bacilli, such as Escherichia coli, Klebsiella pneumoniae, and Proteus species [1]. |
Cefoperazone (sodium salt) |
C3913-5000 |
ApexBio |
5 g |
EUR 267 |
Description: Cefoperazone is a new semisynthetic cephalosporin with a broad spectrum of antibacterial activity. Cefoperazone shows high activity against gram-positive bacteria and gram-negative bacilli, such as Escherichia coli, Klebsiella pneumoniae, and Proteus species [1]. |
Moxalactam (sodium salt) |
C4121-1000 |
ApexBio |
1 g |
EUR 225 |
Description: Moxalactam (sodium salt) is a ?-lactam antibiotic.?-lactam antibiotics (beta-lactam antibiotics) are a class of broad-spectrum antibiotics that contain a beta-lactam ring in their molecular structures. Most ?-lactam antibiotics act by inhibiting cell wall biosynthesis. |
Moxalactam (sodium salt) |
C4121-250 |
ApexBio |
250 mg |
EUR 112 |
Description: Moxalactam (sodium salt) is a ?-lactam antibiotic.?-lactam antibiotics (beta-lactam antibiotics) are a class of broad-spectrum antibiotics that contain a beta-lactam ring in their molecular structures. Most ?-lactam antibiotics act by inhibiting cell wall biosynthesis. |
Moxalactam (sodium salt) |
C4121-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 113 |
Description: Moxalactam (sodium salt) is a ?-lactam antibiotic.?-lactam antibiotics (beta-lactam antibiotics) are a class of broad-spectrum antibiotics that contain a beta-lactam ring in their molecular structures. Most ?-lactam antibiotics act by inhibiting cell wall biosynthesis. |
Moxalactam (sodium salt) |
C4121-500 |
ApexBio |
500 mg |
EUR 168 |
Description: Moxalactam (sodium salt) is a ?-lactam antibiotic.?-lactam antibiotics (beta-lactam antibiotics) are a class of broad-spectrum antibiotics that contain a beta-lactam ring in their molecular structures. Most ?-lactam antibiotics act by inhibiting cell wall biosynthesis. |
Cefazolin (sodium salt) |
C4183-1000 |
ApexBio |
1 g |
EUR 168 |
Description: Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1]. |
Cefazolin (sodium salt) |
C4183-250 |
ApexBio |
250 mg |
EUR 105 |
Description: Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1]. |
Cefazolin (sodium salt) |
C4183-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 113 |
Description: Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1]. |
Cefazolin (sodium salt) |
C4183-500 |
ApexBio |
500 mg |
EUR 138 |
Description: Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1]. |
Tazobactam (sodium salt) |
C4245-1000 |
ApexBio |
1 g |
EUR 226 |
Description: Tazobactam is a ?-lactamase inhibitor [1]. Tazobactam shows intrinsic activity against Acinetobacter strains. The ?-Lactamases are responsible for resistance to penicillins, extended-spectrum cephalosporins, monobactams, and carbapenems. |
Tazobactam (sodium salt) |
C4245-250 |
ApexBio |
250 mg |
EUR 116 |
Description: Tazobactam is a ?-lactamase inhibitor [1]. Tazobactam shows intrinsic activity against Acinetobacter strains. The ?-Lactamases are responsible for resistance to penicillins, extended-spectrum cephalosporins, monobactams, and carbapenems. |
Tazobactam (sodium salt) |
C4245-500 |
ApexBio |
500 mg |
EUR 168 |
Description: Tazobactam is a ?-lactamase inhibitor [1]. Tazobactam shows intrinsic activity against Acinetobacter strains. The ?-Lactamases are responsible for resistance to penicillins, extended-spectrum cephalosporins, monobactams, and carbapenems. |
Clavulanate (potassium salt) |
C4271-25 |
ApexBio |
25 mg |
EUR 122 |
Description: Clavulanate is a metabolite existed in cultures of Streptomyces clavuligerusa with activity against both Gram-positive and Gram-negative bacteria. Clavulanate is a first clinically useful broad-spectrum ?-lactamase inhibitor. |
Clavulanate (potassium salt) |
C4271-50 |
ApexBio |
50 mg |
EUR 147 |
Description: Clavulanate is a metabolite existed in cultures of Streptomyces clavuligerusa with activity against both Gram-positive and Gram-negative bacteria. Clavulanate is a first clinically useful broad-spectrum ?-lactamase inhibitor. |
VU0364572 (trifluoroacetate salt) |
C4396-1 |
ApexBio |
1 mg |
EUR 115 |
Description: IC50: 477 ± 172 nMVU0364572 is a M1 agonist.Alzheimer's disease (AD) is the leading cause of dementia worldwide, and no disease-modifying therapy is availables. |
VU0364572 (trifluoroacetate salt) |
C4396-10 |
ApexBio |
10 mg |
EUR 573 |
Description: IC50: 477 ± 172 nMVU0364572 is a M1 agonist.Alzheimer's disease (AD) is the leading cause of dementia worldwide, and no disease-modifying therapy is availables. |
VU0364572 (trifluoroacetate salt) |
C4396-25 |
ApexBio |
25 mg |
EUR 1195 |
Description: IC50: 477 ± 172 nMVU0364572 is a M1 agonist.Alzheimer's disease (AD) is the leading cause of dementia worldwide, and no disease-modifying therapy is availables. |
VU0364572 (trifluoroacetate salt) |
C4396-5 |
ApexBio |
5 mg |
EUR 345 |
Description: IC50: 477 ± 172 nMVU0364572 is a M1 agonist.Alzheimer's disease (AD) is the leading cause of dementia worldwide, and no disease-modifying therapy is availables. |
Simvastatin (sodium salt) |
C4426-100 |
ApexBio |
100 mg |
EUR 392 |
Description: Ki: 0.12 nMSimvastatin is a HMG-CoA reductase inhibitor. HMG-CoA reductase has been found to be the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the ?statin? class of cholesterol-lowering drugs. |
Simvastatin (sodium salt) |
C4426-25 |
ApexBio |
25 mg |
EUR 196 |
Description: Ki: 0.12 nMSimvastatin is a HMG-CoA reductase inhibitor. HMG-CoA reductase has been found to be the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the ?statin? class of cholesterol-lowering drugs. |
Moniliformin (sodium salt) |
C4459-1 |
ApexBio |
1 mg |
EUR 321 |
Description: Moniliformin induces mitotic arrest at the metaphase stage.Mitosis is a part of the cell cycle when replicated chromosomes are separated into two new nuclei. |
Cefotaxime (sodium salt) |
C4588-1000 |
ApexBio |
1 g |
EUR 126 |
Description: MIC: <0.1 ?g/ml for S. pneumoniae Cefotaxime is a cephalosporin antibiotic. |
Cefotaxime (sodium salt) |
C4588-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 113 |
Description: MIC: <0.1 ?g/ml for S. pneumoniae Cefotaxime is a cephalosporin antibiotic. |
Cefotaxime (sodium salt) |
C4588-500 |
ApexBio |
500 mg |
EUR 108 |
Description: MIC: <0.1 ?g/ml for S. pneumoniae Cefotaxime is a cephalosporin antibiotic. |
Cefotaxime (sodium salt) |
C4588-5000 |
ApexBio |
5 g |
EUR 151 |
Description: MIC: <0.1 ?g/ml for S. pneumoniae Cefotaxime is a cephalosporin antibiotic. |
Lorglumide (sodium salt) |
C4809-25 |
ApexBio |
25 mg |
EUR 145 |
Description: Lorglumide (sodium salt) is the first nonpeptidic, selective and potent inhibitor of the CCK-A receptor [1][2][3][4] . |
Lorglumide (sodium salt) |
C4809-50 |
ApexBio |
50 mg |
EUR 171 |
Description: Lorglumide (sodium salt) is the first nonpeptidic, selective and potent inhibitor of the CCK-A receptor [1][2][3][4] . |
Piriprost (potassium salt) |
C4828-10 |
ApexBio |
10 mg |
EUR 506 |
Description: Piriprost (U 60257) is a leukotriene synthesis inhibitor [1].Leukotrienes belong to a family of eicosanoid inflammatory mediators produced in leukocytes. Leukotrienes mainly act on a subfamily of G protein-coupled receptors. |
Piriprost (potassium salt) |
C4828-5 |
ApexBio |
5 mg |
EUR 308 |
Description: Piriprost (U 60257) is a leukotriene synthesis inhibitor [1].Leukotrienes belong to a family of eicosanoid inflammatory mediators produced in leukocytes. Leukotrienes mainly act on a subfamily of G protein-coupled receptors. |
Piriprost (potassium salt) |
C4828-50 |
ApexBio |
50 mg |
EUR 2048 |
Description: Piriprost (U 60257) is a leukotriene synthesis inhibitor [1].Leukotrienes belong to a family of eicosanoid inflammatory mediators produced in leukocytes. Leukotrienes mainly act on a subfamily of G protein-coupled receptors. |
Cefoxitin (sodium salt) |
C4849-1000 |
ApexBio |
1 g |
EUR 241 |
Description: Cefoxitin (sodium salt) is a second generation cephalosporin antibiotic that was used to treat a wide range of gram-negative and gram-positive bacteria [1][2]. |
Cefoxitin (sodium salt) |
C4849-250 |
ApexBio |
250 mg |
EUR 113 |
Description: Cefoxitin (sodium salt) is a second generation cephalosporin antibiotic that was used to treat a wide range of gram-negative and gram-positive bacteria [1][2]. |
Cefoxitin (sodium salt) |
C4849-500 |
ApexBio |
500 mg |
EUR 164 |
Description: Cefoxitin (sodium salt) is a second generation cephalosporin antibiotic that was used to treat a wide range of gram-negative and gram-positive bacteria [1][2]. |
Fosmidomycin (sodium salt) |
C4898-10 |
ApexBio |
10 mg |
EUR 415 |
Description: Fosmidomycin is a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXP) [1]. Fosmidomycin is an antibiotic originally isolated from bacteria of the genus Streptomyces. |
Fosmidomycin (sodium salt) |
C4898-25 |
ApexBio |
25 mg |
EUR 830 |
Description: Fosmidomycin is a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXP) [1]. Fosmidomycin is an antibiotic originally isolated from bacteria of the genus Streptomyces. |