The construction and regulation of protein phosphatases.

 

 

• 4 main serine/threonine-specific protein phosphatase catalytic subunits are current within the cytoplasm of animal cells. Three of those enzymes, PP-1, PP-2A, and PP-2B, are members of the identical gene household, whereas PP-2C seems to be distinct. PP-1, PP-2A, and PP-2B are complexed to different subunits in vivo, whereas PP-2C has solely been remoted as a monomeric protein. PP-1, PP-2A, and PP-2C have broad and overlapping specificities in vitro, and account for just about all measurable exercise in tissue extracts towards a wide range of phosphoproteins that regulate metabolism, muscle contractility, and different processes.

 

 

• Their exact capabilities in vivo are unknown, though necessary clues to the physiological roles of PP-1 and PP-2A are supplied by the results of okadaic acid and by the subcellular localization of PP-1. The energetic types of PP-1 are largely particulate, and their affiliation with subcellular buildings is mediated by “targetting subunits” that direct PP-1 to specific areas, improve its exercise towards sure substrates, and confer necessary regulatory properties upon it.

 

Fosamprenavir Calcium Salt | MLN4924 HCl salt

 

• This idea is finest established for the glycogen-bound enzymes in skeletal muscle and liver (PP-1G) and the myofibrillar type (PP-1M) in skeletal muscle. The actions of PP-1 and PP-2B are managed by the second messengers cyclic AMP and calcium. The exercise of PP-2B depends on calcium and calmodulin, whereas PP-1 is managed in a wide range of ways in which rely upon the type of the enzyme and the tissue. PP-1 may be inhibited by cyclic AMP in a wide range of cells by means of the A-kinase-catalyzed phosphorylation of inhibitor-1 and its isofobrms.

 

 

 

 

 

• Phosphorylation of the glycogen-binding subunit of PP-1G by A-kinase promotes translocation of the catalytic subunit from glycogen particles to cytosol in skeletal muscle, inhibiting the dephosphorylation of glycogen-metabolizing enzymes.

 

 

Tariquidar methanesulfonate, hydrate

 

• Allosteric inhibition of hepatic PP-1G by phosphorylase a happens in response to alerts that elevate cyclic AMP or calcium, and prevents the activation of glycogen synthase in liver. PP-1 can be activated not directly by calcium by means of the power of PP-2B to dephosphorylate inhibitor-1.

 

 

 

 

• This management mechanism might function in dopaminoceptive neurones of the mind and different cells. The inactive cytosolic type of PP-1 (PP-1I) may be activated in vitro by means of the glycogen synthase kinase-3-catalyzed phosphorylation of its inhibitory subunit (inhibitor-2), however the physiological significance is unclear.(ABSTRACT TRUNCATED AT 400 WORDS)

 

 

17-DMAG, Hydrochloride Salt, >98%
BC024-001	GenDepot	1mg	EUR 178

17-DMAG, Hydrochloride Salt, >98%
BC024-005	GenDepot	5mg	EUR 286

17-DMAG, Hydrochloride Salt, >98%
BC024-010	GenDepot	10mg	EUR 408

17-DMAG, Hydrochloride Salt, >98%
BC024-025	GenDepot	25mg	Ask for price

17-DMAG, Hydrochloride Salt, >99%
BC024-100	GenDepot	100mg	Ask for price

17-DMAG, Hydrochloride Salt, >99%
BC024-101	GenDepot	1g	Ask for price

17-DMAG, Hydrochloride Salt, >99%
BC024-250	GenDepot	250mg	Ask for price

OSU-03012, Hydrochloride Salt, >98%
BC061-005	GenDepot	5mg	EUR 313

OSU-03012, Hydrochloride Salt, >98%
BC061-025	GenDepot	25mg	EUR 529

Bile salt
BB0225	BBI Biotech	25g	EUR 79.58
Product category: Biochemicals/Detergents/Surfactants

Stachydrine (hydrochloride)
C3648-100	ApexBio	100 mg	EUR 119
Description: Stachydrine is an anti-metastatic agent.Stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits.

Stachydrine (hydrochloride)
C3648-1000	ApexBio	1 g	EUR 467
Description: Stachydrine is an anti-metastatic agent.Stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits.

Stachydrine (hydrochloride)
C3648-250	ApexBio	250 mg	EUR 206
Description: Stachydrine is an anti-metastatic agent.Stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits.

Stachydrine (hydrochloride)
C3648-500	ApexBio	500 mg	EUR 328
Description: Stachydrine is an anti-metastatic agent.Stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits.

Barnidipine (hydrochloride)
C3727-100	ApexBio	100 mg	EUR 203
Description: Barnidipine is a calcium-channel blocker.A calcium channel, an ion channel which displays selective permeability to calcium ions, is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels.

Barnidipine (hydrochloride)
C3727-50	ApexBio	50 mg	EUR 155
Description: Barnidipine is a calcium-channel blocker.A calcium channel, an ion channel which displays selective permeability to calcium ions, is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels.

MS049 (hydrochloride)
C3776-10	ApexBio	10 mg	EUR 200
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)
C3776-100	ApexBio	100 mg	EUR 1181
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)
C3776-25	ApexBio	25 mg	EUR 382
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)
C3776-5	ApexBio	5 mg	EUR 139
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)
C3776-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 150
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)
C3776-50	ApexBio	50 mg	EUR 653
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

Guanabenz (hydrochloride)
C3786-100	ApexBio	100 mg	EUR 231
Description: Guanabenz is an orally active ?2-adrenoceptor agonist with hypotensive effects [1]. The ?2 adrenergic receptors belong to a family of G protein-coupled receptor (GPCR), mediate many physiological actions of the endogenous catecholamines adrenaline and noradrenaline.

Guanabenz (hydrochloride)
C3786-50	ApexBio	50 mg	EUR 144
Description: Guanabenz is an orally active ?2-adrenoceptor agonist with hypotensive effects [1]. The ?2 adrenergic receptors belong to a family of G protein-coupled receptor (GPCR), mediate many physiological actions of the endogenous catecholamines adrenaline and noradrenaline.

Ulixertinib (hydrochloride)
C3921-10	ApexBio	10 mg	EUR 406
Description: Ulixertinib, also named as BVD-523, is a novel and reversible inhibitor of ERK1/2. Ulixertinib potently and selectively inhibits the activity of ERK1 and ERK2 kinases in a reversible, ATP-competitive fashion [1].

Ulixertinib (hydrochloride)
C3921-25	ApexBio	25 mg	EUR 661
Description: Ulixertinib, also named as BVD-523, is a novel and reversible inhibitor of ERK1/2. Ulixertinib potently and selectively inhibits the activity of ERK1 and ERK2 kinases in a reversible, ATP-competitive fashion [1].

Ulixertinib (hydrochloride)
C3921-5	ApexBio	5 mg	EUR 250
Description: Ulixertinib, also named as BVD-523, is a novel and reversible inhibitor of ERK1/2. Ulixertinib potently and selectively inhibits the activity of ERK1 and ERK2 kinases in a reversible, ATP-competitive fashion [1].

Chlorcyclizine (hydrochloride)
C3989-100	ApexBio	100 mg	EUR 118
Description: Chlorcyclizine is a phenylpiperazine antagonist for histamine H1 receptor [1]. The histamine has been involved in modulating many physiological functions of the hypothalamus, such as arousal state, feeding, locomotor activity, and drinking.

Chlorcyclizine (hydrochloride)
C3989-1000	ApexBio	1 g	EUR 595
Description: Chlorcyclizine is a phenylpiperazine antagonist for histamine H1 receptor [1]. The histamine has been involved in modulating many physiological functions of the hypothalamus, such as arousal state, feeding, locomotor activity, and drinking.

Chlorcyclizine (hydrochloride)
C3989-250	ApexBio	250 mg	EUR 210
Description: Chlorcyclizine is a phenylpiperazine antagonist for histamine H1 receptor [1]. The histamine has been involved in modulating many physiological functions of the hypothalamus, such as arousal state, feeding, locomotor activity, and drinking.

Chlorcyclizine (hydrochloride)
C3989-500	ApexBio	500 mg	EUR 357
Description: Chlorcyclizine is a phenylpiperazine antagonist for histamine H1 receptor [1]. The histamine has been involved in modulating many physiological functions of the hypothalamus, such as arousal state, feeding, locomotor activity, and drinking.

Lofexidine (hydrochloride)
C3990-1000	ApexBio	1 g	EUR 126
Description: Lofexidine is a ?2-Receptor agonist for opioid detoxification. Lofexidine shows a strong affinity for the ?2A-receptor subtype [1].

Lofexidine (hydrochloride)
C3990-5.1	ApexBio	10 mM (in 1mL H2O)	EUR 113
Description: Lofexidine is a ?2-Receptor agonist for opioid detoxification. Lofexidine shows a strong affinity for the ?2A-receptor subtype [1].

Lofexidine (hydrochloride)
C3990-500	ApexBio	500 mg	EUR 100
Description: Lofexidine is a ?2-Receptor agonist for opioid detoxification. Lofexidine shows a strong affinity for the ?2A-receptor subtype [1].

Nortriptyline (hydrochloride)
C4077-100	ApexBio	100 mg	EUR 163
Description: Ki: 3.4 nM: blocks the norepinephrine transporter.Ki: 161 nM: inhibits the serotonin transporter.

Nortriptyline (hydrochloride)
C4077-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 113
Description: Ki: 3.4 nM: blocks the norepinephrine transporter.Ki: 161 nM: inhibits the serotonin transporter.

Nortriptyline (hydrochloride)
C4077-50	ApexBio	50 mg	EUR 116
Description: Ki: 3.4 nM: blocks the norepinephrine transporter.Ki: 161 nM: inhibits the serotonin transporter.

Imipramine (hydrochloride)
C4117-5.1	ApexBio	10 mM (in 1mL H2O)	EUR 113
Description: Imipramine (hydrochloride) is a tricyclic antidepressant and is mainly used in the treatment of major depression and enuresis [1]. Antidepressants are antagonists of many neurotransmitter receptors in human brain [3].

Imipramine (hydrochloride)
C4117-5000	ApexBio	5 g	EUR 108
Description: Imipramine (hydrochloride) is a tricyclic antidepressant and is mainly used in the treatment of major depression and enuresis [1]. Antidepressants are antagonists of many neurotransmitter receptors in human brain [3].

Clorgyline (hydrochloride)
C4137-100	ApexBio	100 mg	EUR 224
Description: Clorgyline (hydrochloride) is an irreversible, potent and selective monoamine oxidase (MAO) A inhibitor with Ki values of 0.054 and 58 ?M and IC50 values of 0.0012 and 1.9 ?M for MAO-A and MAO-B, respectively [1][2].

Clorgyline (hydrochloride)
C4137-25	ApexBio	25 mg	EUR 110
Description: Clorgyline (hydrochloride) is an irreversible, potent and selective monoamine oxidase (MAO) A inhibitor with Ki values of 0.054 and 58 ?M and IC50 values of 0.0012 and 1.9 ?M for MAO-A and MAO-B, respectively [1][2].

Clorgyline (hydrochloride)
C4137-50	ApexBio	50 mg	EUR 154
Description: Clorgyline (hydrochloride) is an irreversible, potent and selective monoamine oxidase (MAO) A inhibitor with Ki values of 0.054 and 58 ?M and IC50 values of 0.0012 and 1.9 ?M for MAO-A and MAO-B, respectively [1][2].

Doxepin (hydrochloride)
C4153-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 113
Description: Doxepin, a tricyclic antidepressant, is a potent histamine H1 antagonist [1]. The histamine receptors belong to a family of G protein?coupled receptors activated by their primary endogenous ligand histamine.

Doxepin (hydrochloride)
C4153-5000	ApexBio	5 g	EUR 168
Description: Doxepin, a tricyclic antidepressant, is a potent histamine H1 antagonist [1]. The histamine receptors belong to a family of G protein?coupled receptors activated by their primary endogenous ligand histamine.

Anhydrochlortetracycline (hydrochloride)
C4218-1	ApexBio	1 mg	EUR 132
Description: Anhydrochlortetracycline was produced by the acid degradation of chlortetracycline. Anhydrochlortetracycline only have a fraction of the antibacterial activity of chlortetracycline. Anhydrochlortetracycline strongly inhibited the growth of Streptomyces aureofaciem.

Anhydrochlortetracycline (hydrochloride)
C4218-5	ApexBio	5 mg	EUR 255
Description: Anhydrochlortetracycline was produced by the acid degradation of chlortetracycline. Anhydrochlortetracycline only have a fraction of the antibacterial activity of chlortetracycline. Anhydrochlortetracycline strongly inhibited the growth of Streptomyces aureofaciem.

Anhydrotetracycline (hydrochloride)
C4291-100	ApexBio	100 mg	EUR 241
Description: Anhydrotetracycline (hydrochloride) (ATC) is a powerful effector for the tetracycline repressor (TetR) and reverse tetracycline repressor (revTetR) systems [1].

Anhydrotetracycline (hydrochloride)
C4291-25	ApexBio	25 mg	EUR 123
Description: Anhydrotetracycline (hydrochloride) (ATC) is a powerful effector for the tetracycline repressor (TetR) and reverse tetracycline repressor (revTetR) systems [1].

Anhydrotetracycline (hydrochloride)
C4291-50	ApexBio	50 mg	EUR 171
Description: Anhydrotetracycline (hydrochloride) (ATC) is a powerful effector for the tetracycline repressor (TetR) and reverse tetracycline repressor (revTetR) systems [1].

(±)-Salsolinol (hydrochloride)
C4364-500	ApexBio	500 mg	EUR 308
Description: (±)-Salsolinol targets depolarize dopamineric neurons. Dopaminergic neurons produce dopamine, a neurotransmitter with various roles in neurological functions.

Midodrine (hydrochloride)
C4493-100	ApexBio	100 mg	EUR 113
Description: Ki: 2, 6.9, and 1.7 ?M for ?1A, ?1B, ?1D, respectivelyMidodrine is the prodrug of the ?1-adrenergic receptor agonist, 1-(2?,5?-dimethoxyphenyl)-2-aminoethanol.

Midodrine (hydrochloride)
C4493-250	ApexBio	250 mg	EUR 200
Description: Ki: 2, 6.9, and 1.7 ?M for ?1A, ?1B, ?1D, respectivelyMidodrine is the prodrug of the ?1-adrenergic receptor agonist, 1-(2?,5?-dimethoxyphenyl)-2-aminoethanol.

Celiprolol (hydrochloride)
C4521-10	ApexBio	10 mg	EUR 254
Description: Celiprolol is a ?1 adrenergic receptor antagonist and ?2 adrenergic receptor partial agonist.?2 adrenergic receptor agonists, also known as adrenergic ?2 receptor agonists, are a class of drugs acting on the ?2 adrenergic receptor.

Celiprolol (hydrochloride)
C4521-25	ApexBio	25 mg	EUR 500
Description: Celiprolol is a ?1 adrenergic receptor antagonist and ?2 adrenergic receptor partial agonist.?2 adrenergic receptor agonists, also known as adrenergic ?2 receptor agonists, are a class of drugs acting on the ?2 adrenergic receptor.

Celiprolol (hydrochloride)
C4521-5	ApexBio	5 mg	EUR 183
Description: Celiprolol is a ?1 adrenergic receptor antagonist and ?2 adrenergic receptor partial agonist.?2 adrenergic receptor agonists, also known as adrenergic ?2 receptor agonists, are a class of drugs acting on the ?2 adrenergic receptor.

Aceclidine (hydrochloride)
C4635-1000	ApexBio	1 g	EUR 328

Aceclidine (hydrochloride)
C4635-500	ApexBio	500 mg	EUR 206

Trimidox (hydrochloride)
C4714-10	ApexBio	10 mg	EUR 184
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis.

Trimidox (hydrochloride)
C4714-25	ApexBio	25 mg	EUR 370
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis.

Trimidox (hydrochloride)
C4714-5	ApexBio	5 mg	EUR 121
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis.

Trimidox (hydrochloride)
C4714-50	ApexBio	50 mg	EUR 618
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis.

Cycloguanil (hydrochloride)
C5763-10	ApexBio	10 mg	EUR 109
Description: Cycloguanil is an inhibitor of dihydrofolate reductase (DHFR)[1].Dihydrofolate reductase (DHFR) is an enzyme that involved in reducing dihydrofolic acid to tetrahydrofolic acid.

Cycloguanil (hydrochloride)
C5763-25	ApexBio	25 mg	EUR 163
Description: Cycloguanil is an inhibitor of dihydrofolate reductase (DHFR)[1].Dihydrofolate reductase (DHFR) is an enzyme that involved in reducing dihydrofolic acid to tetrahydrofolic acid.

Cycloguanil (hydrochloride)
C5763-50	ApexBio	50 mg	EUR 206
Description: Cycloguanil is an inhibitor of dihydrofolate reductase (DHFR)[1].Dihydrofolate reductase (DHFR) is an enzyme that involved in reducing dihydrofolic acid to tetrahydrofolic acid.

VU590 (hydrochloride)
C4778-10	ApexBio	10 mg	EUR 195

VU590 (hydrochloride)
C4778-25	ApexBio	25 mg	EUR 389

VU590 (hydrochloride)
C4778-5	ApexBio	5 mg	EUR 139

Bufuralol (hydrochloride)
C5043-1	ApexBio	1 mg	EUR 139
Description: Bufuralol is a non-specific ?-adrenergic blocker. Beta adrenergic agonists are medications relaxing muscles of the airways, which widens the airways and leads to easier breathing.

Bufuralol (hydrochloride)
C5043-10	ApexBio	10 mg	EUR 628
Description: Bufuralol is a non-specific ?-adrenergic blocker. Beta adrenergic agonists are medications relaxing muscles of the airways, which widens the airways and leads to easier breathing.

Bufuralol (hydrochloride)
C5043-5	ApexBio	5 mg	EUR 457
Description: Bufuralol is a non-specific ?-adrenergic blocker. Beta adrenergic agonists are medications relaxing muscles of the airways, which widens the airways and leads to easier breathing.

AN3365 (hydrochloride)
C5068-10	ApexBio	10 mg	EUR 328
Description: AN3365 is a potent and selective leucyl-tRNA synthetase inhibitor [1].The leucyl-tRNA synthetase belongs to a member of the class I aminoacyl-tRNA synthetase family.

AN3365 (hydrochloride)
C5068-25	ApexBio	25 mg	EUR 659
Description: AN3365 is a potent and selective leucyl-tRNA synthetase inhibitor [1].The leucyl-tRNA synthetase belongs to a member of the class I aminoacyl-tRNA synthetase family.

AN3365 (hydrochloride)
C5068-5	ApexBio	5 mg	EUR 206
Description: AN3365 is a potent and selective leucyl-tRNA synthetase inhibitor [1].The leucyl-tRNA synthetase belongs to a member of the class I aminoacyl-tRNA synthetase family.

Calindol (hydrochloride)
C5329-10	ApexBio	10 mg	EUR 440
Description: Calindol is an activator of the calcium-sensing receptor (CaSR).The extracellular calciumsensing receptor (CaSR), a G protein-coupled receptor (GPCR), senses extracellular calcium[Ca2+]e and regulates calciumion homeostasis.

Calindol (hydrochloride)
C5329-25	ApexBio	25 mg	EUR 902
Description: Calindol is an activator of the calcium-sensing receptor (CaSR).The extracellular calciumsensing receptor (CaSR), a G protein-coupled receptor (GPCR), senses extracellular calcium[Ca2+]e and regulates calciumion homeostasis.

Calindol (hydrochloride)
C5329-5	ApexBio	5 mg	EUR 270
Description: Calindol is an activator of the calcium-sensing receptor (CaSR).The extracellular calciumsensing receptor (CaSR), a G protein-coupled receptor (GPCR), senses extracellular calcium[Ca2+]e and regulates calciumion homeostasis.

Kasugamycin (hydrochloride)
C5503-10000	ApexBio	10 g	EUR 350
Description: Kasugamycin is an aminoglycosidic antibiotic. Aminoglycoside, a medicinal and bacteriologic category of traditional Gram-negative antibacterial therapeutic agent, inhibits protein synthesis and contains as a portion of the molecule an amino-modified glycoside.

Kasugamycin (hydrochloride)
C5503-5000	ApexBio	5 g	EUR 251
Description: Kasugamycin is an aminoglycosidic antibiotic. Aminoglycoside, a medicinal and bacteriologic category of traditional Gram-negative antibacterial therapeutic agent, inhibits protein synthesis and contains as a portion of the molecule an amino-modified glycoside.

Ciprofloxacin (hydrochloride)
C5539-10000	ApexBio	10 g	EUR 116
Description: Ciprofloxacin (hydrochloride) is a fluoroquinolone antibiotic that has antimicrobial and immunomodulatory activities [1].

Ciprofloxacin (hydrochloride)
C5539-25000	ApexBio	25 g	EUR 154
Description: Ciprofloxacin (hydrochloride) is a fluoroquinolone antibiotic that has antimicrobial and immunomodulatory activities [1].

 

CTLA-Four and PD-1 receptors inhibit T-cell activation by distinct mechanisms.

 

• CTLA-Four and PD-1 are receptors that negatively regulate T-cell activation. Ligation of each CTLA-Four and PD-1 blocked CD3/CD28-mediated upregulation of glucose metabolism and Akt exercise, however every achieved this regulation utilizing separate mechanisms.

 

 

• CTLA-4-mediated inhibition of Akt phosphorylation is delicate to okadaic acid, offering direct proof that PP2A performs a distinguished function in mediating CTLA-Four suppression of T-cell activation. In distinction, PD-1 signaling inhibits Akt phosphorylation by stopping CD28-mediated activation of phosphatidylinositol 3-kinase (PI3K).

 

Palbociclib (PD0332991) Isethionate

 

• The power of PD-1 to suppress PI3K/AKT activation was dependent upon the immunoreceptor tyrosine-based change motif positioned in its cytoplasmic tail, including additional significance to this area in mediating PD-1 sign transduction.

 

 

 

• Lastly, PD-1 ligation is more practical in suppressing CD3/CD28-induced adjustments within the T-cell transcriptional profile, suggesting that differential regulation of PI3K activation by PD-1 and CTLA-Four ligation ends in distinct mobile phenotypes. Collectively, these knowledge counsel that CTLA-Four and PD-1 inhibit T-cell activation by means of distinct and doubtlessly synergistic mechanisms.

 

 

• The inhibitory impact of a marine-sponge toxin, okadaic acid, was examined on kind 1, kind 2A, kind 2B and kind 2C protein phosphatases in addition to on a polycation-modulated (PCM) phosphatase. Of the protein phosphatases examined, the catalytic subunit of kind 2A phosphatase from rabbit skeletal muscle was most potently inhibited. For the phosphorylated myosin light-chain

 

Colistin Methanesulfonate (sodium salt)
C3046-1000	ApexBio	1 g	EUR 174
Description: Colistin methanesulfonate is an inactive prodrug of colistin (also known as polymyxin E), which is an antibiotic with effect against most Gram-negative bacteria, but also causes nephro- and neurotoxicity [1].

Colistin Methanesulfonate (sodium salt)
C3046-5000	ApexBio	5 g	EUR 612
Description: Colistin methanesulfonate is an inactive prodrug of colistin (also known as polymyxin E), which is an antibiotic with effect against most Gram-negative bacteria, but also causes nephro- and neurotoxicity [1].

Abemaciclib (methanesulfonate)
HY-16297	MedChemExpress	500mg	EUR 452

Ethyl methanesulfonate
GX0446-100G	Glentham Life Sciences	100 g	EUR 261

Ethyl methanesulfonate
GX0446-10G	Glentham Life Sciences	10 g	EUR 74

Ethyl methanesulfonate
GX0446-25G	Glentham Life Sciences	25 g	EUR 118

Ethyl methanesulfonate
GX0446-5G	Glentham Life Sciences	5 g	EUR 54

Silver methanesulfonate
GX5020-25G	Glentham Life Sciences	25 g	EUR 174

Silver methanesulfonate
GX5020-5G	Glentham Life Sciences	5 g	EUR 71

Tricaine methanesulfonate
GE5936-10G	Glentham Life Sciences	10 g	EUR 57

Tricaine methanesulfonate
GE5936-25G	Glentham Life Sciences	25 g	EUR 82

Tricaine methanesulfonate
GE5936-50G	Glentham Life Sciences	50 g	EUR 118

Tricaine methanesulfonate
GE5936-5G	Glentham Life Sciences	5 g	EUR 47

Ethyl methanesulfonate
20-abx186442	Abbexa	EUR 565.00 EUR 300.00 EUR 217.00	100 g 25 g 5 g
Shipped within 1-2 weeks.

Pridinol Methanesulfonate
A8507-1000	ApexBio	1 g	EUR 431
Description: Pridinol Methanesulfonate Salt is used as an anticholinergic and as an antiparkinsonian agent.

Pridinol Methanesulfonate
A8507-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 108
Description: Pridinol Methanesulfonate Salt is used as an anticholinergic and as an antiparkinsonian agent.

Pridinol Methanesulfonate
A8507-50	ApexBio	50 mg	EUR 128
Description: Pridinol Methanesulfonate Salt is used as an anticholinergic and as an antiparkinsonian agent.

Pridinol Methanesulfonate
A8507-5000	ApexBio	5 g	EUR 999
Description: Pridinol Methanesulfonate Salt is used as an anticholinergic and as an antiparkinsonian agent.

Colistin Sodium Methanesulfonate
C073-10G	TOKU-E	10 g	EUR 820

Colistin Sodium Methanesulfonate
C073-1G	TOKU-E	1 g	EUR 135

Colistin Sodium Methanesulfonate
C073-5G	TOKU-E	5 g	EUR 440

Tariquidar (methanesulfonate, hydrate)
HY-10550A	MedChemExpress	100mg	EUR 612

Hydroxystilbamidine bis(methanesulfonate)
HY-108166A	MedChemExpress	5mg	EUR 533

PF-06424439 (methanesulfonate)
HY-108341A	MedChemExpress	10mM/1mL	EUR 146

BCX 1470 (methanesulfonate)
HY-50875	MedChemExpress	10mM/1mL	EUR 580

PF-04217903 (methanesulfonate)
HY-12017A	MedChemExpress	10mM/1mL	EUR 156

Colistin sodium methanesulfonate
GA2961-1G	Glentham Life Sciences	1 g	EUR 126

Colistin sodium methanesulfonate
GA2961-5G	Glentham Life Sciences	5 g	EUR 293

2-Chloroethyl methanesulfonate
20-abx183170	Abbexa	EUR 495.00 EUR 272.00	25 g 5 g
Shipped within 1-2 weeks.

PF-04217903 methanesulfonate
A3712-100	ApexBio	100 mg	EUR 595
Description: PF-04217903 is an ATP-competitive small-molecule inhibitor of c-Met kinase with Ki value of 4.8 nM [1].The c-Met kinase is a kind of receptor tyrosine kinases (RTK) and plays critical roles in embryonic development and wound healing.

PF-04217903 methanesulfonate
A3712-25	ApexBio	25 mg	EUR 293
Description: PF-04217903 is an ATP-competitive small-molecule inhibitor of c-Met kinase with Ki value of 4.8 nM [1].The c-Met kinase is a kind of receptor tyrosine kinases (RTK) and plays critical roles in embryonic development and wound healing.

PF-04217903 methanesulfonate
A3712-5	ApexBio	5 mg	EUR 131
Description: PF-04217903 is an ATP-competitive small-molecule inhibitor of c-Met kinase with Ki value of 4.8 nM [1].The c-Met kinase is a kind of receptor tyrosine kinases (RTK) and plays critical roles in embryonic development and wound healing.

Tariquidar methanesulfonate, hydrate
A3859-10	ApexBio	10 mg	EUR 189
Description: Tariquidar methanesulfonate, hydrate is a potent inhibitor of P-glycoprotein (Pgp), a 170-kDa transmembrane protein acting as a drug efflux pump to actively transport structurally unrelated compounds out of cell, which noncompetitively inhibits the basal the activity of ATPase associated with Pgp.

Tariquidar methanesulfonate, hydrate
A3859-50	ApexBio	50 mg	EUR 444
Description: Tariquidar methanesulfonate, hydrate is a potent inhibitor of P-glycoprotein (Pgp), a 170-kDa transmembrane protein acting as a drug efflux pump to actively transport structurally unrelated compounds out of cell, which noncompetitively inhibits the basal the activity of ATPase associated with Pgp.

Ethyl 3-Aminobenzoate (methanesulfonate)
C3619-100000	ApexBio	100 g	EUR 318
Description: Ethyl 3-Aminobenzoate can block the generation of action potentials via voltage-dependent Na+-channels.Sodium channels play a critical role in physiology: they can rapidly transmit depolarizing impulses throughout cells and cell networks, therefore enabling co-ordination of higher processes.

Ethyl 3-Aminobenzoate (methanesulfonate)
C3619-25000	ApexBio	25 g	EUR 128
Description: Ethyl 3-Aminobenzoate can block the generation of action potentials via voltage-dependent Na+-channels.Sodium channels play a critical role in physiology: they can rapidly transmit depolarizing impulses throughout cells and cell networks, therefore enabling co-ordination of higher processes.

Ethyl 3-Aminobenzoate (methanesulfonate)
C3619-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 113
Description: Ethyl 3-Aminobenzoate can block the generation of action potentials via voltage-dependent Na+-channels.Sodium channels play a critical role in physiology: they can rapidly transmit depolarizing impulses throughout cells and cell networks, therefore enabling co-ordination of higher processes.

Ethyl 3-Aminobenzoate (methanesulfonate)
C3619-50000	ApexBio	50 g	EUR 195
Description: Ethyl 3-Aminobenzoate can block the generation of action potentials via voltage-dependent Na+-channels.Sodium channels play a critical role in physiology: they can rapidly transmit depolarizing impulses throughout cells and cell networks, therefore enabling co-ordination of higher processes.

Ro 31-8220 methanesulfonate
1946-1	Biovision		EUR 137

Ro 31-8220 methanesulfonate
1946-5	Biovision		EUR 381

Bile salt
BB0225	BBI Biotech	25g	EUR 79.58
Product category: Biochemicals/Detergents/Surfactants

Ampicillin Sodium Salt
AK0839-0010	Akron Biotech	10g	Ask for price

Ampicillin Sodium Salt
AK0839-0025	Akron Biotech	25g	Ask for price

Ampicillin Sodium Salt
AK0839-0100	Akron Biotech	100g	Ask for price

NADPH Tetrasodium Salt
AK1395-0100	Akron Biotech	100mg	Ask for price

NADPH Tetrasodium Salt
AK1395-0500	Akron Biotech	500mg	Ask for price

NADPH Tetrasodium Salt
AK1395-1000	Akron Biotech	1g	Ask for price

Heparin Sodium Salt
AK3004-1000	Akron Biotech	1g	Ask for price

Heparin Sodium Salt
AK3004-5000	Akron Biotech	5g	Ask for price

CAPS, sodium salt
CB0097	BBI Biotech	50g	EUR 71.75
Product category: Biochemicals/Biological Buffers/Common Buffers

CAPSO, sodium salt
CD0041	BBI Biotech	50g	EUR 76.1
Product category: Biochemicals/Biological Buffers/Common Buffers

Cefonicid (sodium salt)
C3812-1000	ApexBio	1 g	EUR 406
Description: Cefonicid is a second-generation cephalosporin antibiotic.Cephalosporins, the largest and most diverse family of antibiotics of the beta-lactam group, are structurally and pharmacologically related to the penicillins.

Cefonicid (sodium salt)
C3812-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 113
Description: Cefonicid is a second-generation cephalosporin antibiotic.Cephalosporins, the largest and most diverse family of antibiotics of the beta-lactam group, are structurally and pharmacologically related to the penicillins.

Cefonicid (sodium salt)
C3812-500	ApexBio	500 mg	EUR 251
Description: Cefonicid is a second-generation cephalosporin antibiotic.Cephalosporins, the largest and most diverse family of antibiotics of the beta-lactam group, are structurally and pharmacologically related to the penicillins.

Cefoperazone (sodium salt)
C3913-10000	ApexBio	10 g	EUR 403
Description: Cefoperazone is a new semisynthetic cephalosporin with a broad spectrum of antibacterial activity. Cefoperazone shows high activity against gram-positive bacteria and gram-negative bacilli, such as Escherichia coli, Klebsiella pneumoniae, and Proteus species [1].

Cefoperazone (sodium salt)
C3913-5000	ApexBio	5 g	EUR 267
Description: Cefoperazone is a new semisynthetic cephalosporin with a broad spectrum of antibacterial activity. Cefoperazone shows high activity against gram-positive bacteria and gram-negative bacilli, such as Escherichia coli, Klebsiella pneumoniae, and Proteus species [1].

Moxalactam (sodium salt)
C4121-1000	ApexBio	1 g	EUR 225
Description: Moxalactam (sodium salt) is a ?-lactam antibiotic.?-lactam antibiotics (beta-lactam antibiotics) are a class of broad-spectrum antibiotics that contain a beta-lactam ring in their molecular structures. Most ?-lactam antibiotics act by inhibiting cell wall biosynthesis.

Moxalactam (sodium salt)
C4121-250	ApexBio	250 mg	EUR 112
Description: Moxalactam (sodium salt) is a ?-lactam antibiotic.?-lactam antibiotics (beta-lactam antibiotics) are a class of broad-spectrum antibiotics that contain a beta-lactam ring in their molecular structures. Most ?-lactam antibiotics act by inhibiting cell wall biosynthesis.

Moxalactam (sodium salt)
C4121-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 113
Description: Moxalactam (sodium salt) is a ?-lactam antibiotic.?-lactam antibiotics (beta-lactam antibiotics) are a class of broad-spectrum antibiotics that contain a beta-lactam ring in their molecular structures. Most ?-lactam antibiotics act by inhibiting cell wall biosynthesis.

Moxalactam (sodium salt)
C4121-500	ApexBio	500 mg	EUR 168
Description: Moxalactam (sodium salt) is a ?-lactam antibiotic.?-lactam antibiotics (beta-lactam antibiotics) are a class of broad-spectrum antibiotics that contain a beta-lactam ring in their molecular structures. Most ?-lactam antibiotics act by inhibiting cell wall biosynthesis.

Cefazolin (sodium salt)
C4183-1000	ApexBio	1 g	EUR 168
Description: Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1].

Cefazolin (sodium salt)
C4183-250	ApexBio	250 mg	EUR 105
Description: Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1].

Cefazolin (sodium salt)
C4183-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 113
Description: Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1].

Cefazolin (sodium salt)
C4183-500	ApexBio	500 mg	EUR 138
Description: Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1].

Tazobactam (sodium salt)
C4245-1000	ApexBio	1 g	EUR 226
Description: Tazobactam is a ?-lactamase inhibitor [1]. Tazobactam shows intrinsic activity against Acinetobacter strains. The ?-Lactamases are responsible for resistance to penicillins, extended-spectrum cephalosporins, monobactams, and carbapenems.

Tazobactam (sodium salt)
C4245-250	ApexBio	250 mg	EUR 116
Description: Tazobactam is a ?-lactamase inhibitor [1]. Tazobactam shows intrinsic activity against Acinetobacter strains. The ?-Lactamases are responsible for resistance to penicillins, extended-spectrum cephalosporins, monobactams, and carbapenems.

Tazobactam (sodium salt)
C4245-500	ApexBio	500 mg	EUR 168
Description: Tazobactam is a ?-lactamase inhibitor [1]. Tazobactam shows intrinsic activity against Acinetobacter strains. The ?-Lactamases are responsible for resistance to penicillins, extended-spectrum cephalosporins, monobactams, and carbapenems.

Clavulanate (potassium salt)
C4271-25	ApexBio	25 mg	EUR 122
Description: Clavulanate is a metabolite existed in cultures of Streptomyces clavuligerusa with activity against both Gram-positive and Gram-negative bacteria. Clavulanate is a first clinically useful broad-spectrum ?-lactamase inhibitor.

Clavulanate (potassium salt)
C4271-50	ApexBio	50 mg	EUR 147
Description: Clavulanate is a metabolite existed in cultures of Streptomyces clavuligerusa with activity against both Gram-positive and Gram-negative bacteria. Clavulanate is a first clinically useful broad-spectrum ?-lactamase inhibitor.

VU0364572 (trifluoroacetate salt)
C4396-1	ApexBio	1 mg	EUR 115
Description: IC50: 477 ± 172 nMVU0364572 is a M1 agonist.Alzheimer's disease (AD) is the leading cause of dementia worldwide, and no disease-modifying therapy is availables.

VU0364572 (trifluoroacetate salt)
C4396-10	ApexBio	10 mg	EUR 573
Description: IC50: 477 ± 172 nMVU0364572 is a M1 agonist.Alzheimer's disease (AD) is the leading cause of dementia worldwide, and no disease-modifying therapy is availables.

VU0364572 (trifluoroacetate salt)
C4396-25	ApexBio	25 mg	EUR 1195
Description: IC50: 477 ± 172 nMVU0364572 is a M1 agonist.Alzheimer's disease (AD) is the leading cause of dementia worldwide, and no disease-modifying therapy is availables.

VU0364572 (trifluoroacetate salt)
C4396-5	ApexBio	5 mg	EUR 345
Description: IC50: 477 ± 172 nMVU0364572 is a M1 agonist.Alzheimer's disease (AD) is the leading cause of dementia worldwide, and no disease-modifying therapy is availables.

Simvastatin (sodium salt)
C4426-100	ApexBio	100 mg	EUR 392
Description: Ki: 0.12 nMSimvastatin is a HMG-CoA reductase inhibitor. HMG-CoA reductase has been found to be the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the ?statin? class of cholesterol-lowering drugs.

Simvastatin (sodium salt)
C4426-25	ApexBio	25 mg	EUR 196
Description: Ki: 0.12 nMSimvastatin is a HMG-CoA reductase inhibitor. HMG-CoA reductase has been found to be the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the ?statin? class of cholesterol-lowering drugs.

Moniliformin (sodium salt)
C4459-1	ApexBio	1 mg	EUR 321
Description: Moniliformin induces mitotic arrest at the metaphase stage.Mitosis is a part of the cell cycle when replicated chromosomes are separated into two new nuclei.

Cefotaxime (sodium salt)
C4588-1000	ApexBio	1 g	EUR 126
Description: MIC: <0.1 ?g/ml for S. pneumoniae Cefotaxime is a cephalosporin antibiotic.

Cefotaxime (sodium salt)
C4588-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 113
Description: MIC: <0.1 ?g/ml for S. pneumoniae Cefotaxime is a cephalosporin antibiotic.

Cefotaxime (sodium salt)
C4588-500	ApexBio	500 mg	EUR 108
Description: MIC: <0.1 ?g/ml for S. pneumoniae Cefotaxime is a cephalosporin antibiotic.

Cefotaxime (sodium salt)
C4588-5000	ApexBio	5 g	EUR 151
Description: MIC: <0.1 ?g/ml for S. pneumoniae Cefotaxime is a cephalosporin antibiotic.

Lorglumide (sodium salt)
C4809-25	ApexBio	25 mg	EUR 145
Description: Lorglumide (sodium salt) is the first nonpeptidic, selective and potent inhibitor of the CCK-A receptor [1][2][3][4] .

Lorglumide (sodium salt)
C4809-50	ApexBio	50 mg	EUR 171
Description: Lorglumide (sodium salt) is the first nonpeptidic, selective and potent inhibitor of the CCK-A receptor [1][2][3][4] .

Piriprost (potassium salt)
C4828-10	ApexBio	10 mg	EUR 506
Description: Piriprost (U 60257) is a leukotriene synthesis inhibitor [1].Leukotrienes belong to a family of eicosanoid inflammatory mediators produced in leukocytes. Leukotrienes mainly act on a subfamily of G protein-coupled receptors.

Piriprost (potassium salt)
C4828-5	ApexBio	5 mg	EUR 308
Description: Piriprost (U 60257) is a leukotriene synthesis inhibitor [1].Leukotrienes belong to a family of eicosanoid inflammatory mediators produced in leukocytes. Leukotrienes mainly act on a subfamily of G protein-coupled receptors.

Piriprost (potassium salt)
C4828-50	ApexBio	50 mg	EUR 2048
Description: Piriprost (U 60257) is a leukotriene synthesis inhibitor [1].Leukotrienes belong to a family of eicosanoid inflammatory mediators produced in leukocytes. Leukotrienes mainly act on a subfamily of G protein-coupled receptors.

Cefoxitin (sodium salt)
C4849-1000	ApexBio	1 g	EUR 241
Description: Cefoxitin (sodium salt) is a second generation cephalosporin antibiotic that was used to treat a wide range of gram-negative and gram-positive bacteria [1][2].

Cefoxitin (sodium salt)
C4849-250	ApexBio	250 mg	EUR 113
Description: Cefoxitin (sodium salt) is a second generation cephalosporin antibiotic that was used to treat a wide range of gram-negative and gram-positive bacteria [1][2].

Cefoxitin (sodium salt)
C4849-500	ApexBio	500 mg	EUR 164
Description: Cefoxitin (sodium salt) is a second generation cephalosporin antibiotic that was used to treat a wide range of gram-negative and gram-positive bacteria [1][2].

Fosmidomycin (sodium salt)
C4898-10	ApexBio	10 mg	EUR 415
Description: Fosmidomycin is a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXP) [1]. Fosmidomycin is an antibiotic originally isolated from bacteria of the genus Streptomyces.

Fosmidomycin (sodium salt)
C4898-25	ApexBio	25 mg	EUR 830
Description: Fosmidomycin is a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXP) [1]. Fosmidomycin is an antibiotic originally isolated from bacteria of the genus Streptomyces.